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Study: Testicular cells of adult men could be new source of stem cells

Using the testicular cells of adult men, researchers have grown muscle, nerve and other kinds of tissue.

By Karen Kaplan, Los Angeles Times Staff Writer

Scientists have converted cells from human testes into stem cells that grew into muscle, nerve cells and other kinds of tissue, according to a study published Wednesday in the online edition of Nature.

The stem cells offer another potential alternative to embryonic stem cells for researchers who aim to treat diseases such as diabetes and Parkinson's by replacing damaged or malfunctioning cells with custom-grown replacements.

Scientists have also derived flexible adult stem cells from skin, amniotic fluid and menstrual blood.

The new cells were created from sperm-making cells obtained from testicular biopsies of 22 men.

They are theoretically superior to traditional embryonic stem cells because they can be obtained directly from male patients and used to grow replacement tissue that their bodies won't reject, Sabine Conrad of the University of Tuebingen in Germany and her colleagues wrote.

The cells also have an ethical advantage in that they do not require the destruction of human embryos.

Experiments in mice suggested that reproductive cells -- also known as germ cells -- were good candidates for making stem cells because they naturally express low levels of the "pluripotency" genes that make embryonic stem cells so versatile, said Renee A. Reijo Pera, director of the Center for Human Embryonic Stem Cell Research and Education at Stanford University, who was not involved in the study.

The German researchers obtained biopsy samples from men between the ages of 17 and 81. They extracted the individual testicular cells and grew them in laboratory dishes. After about three weeks, some of the cells formed colonies resembling embryonic stem cells, the team reported.

The so-called germline stem cells grew nearly as fast as embryonic stem cells and produced many of the specialized protein markers associated with embryonic stem cells.

Cells from eight of the patients were injected into mice, where they grew into jumbles of tissue that included cartilage, muscle, nerve cells and other building blocks of glands and internal organs, according to the study.

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Stem cell therapy used to treat cardiac conditions at Bangkok Hospital

Affordable stem cell treatment overseas

 

More at: http://www.latimes.com/features/health/medicine/la-sci-stemcell9-2008oct09,0,6497469.story

 
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